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ERα系列抗体的应用研究(雌激素受体研究值得关注)

发表时间:2021-06-10  |  点击率:777
引言:  雌激素受体alpha (ERα)分布于子宫、睾丸、脑下垂体、肾、附睾、肾上腺、乳腺等组织,其作为核转录因子参与人体多种复杂生理过程的调节。ERα受体表达和调节的研究对多种疾病的预防和治疗有积极意义,例如癌症、代谢性疾病、心血管疾病、神经退行性疾病、炎症和骨质疏松症等[1]。蛋白表达在ERα受体表达调节研究中占有重要地位,而ERα抗体则是ERα受体表达的重要研究工具。 

 

 

       雌激素受体alpha (ERα)分布于子宫、睾丸、脑下垂体、肾、附睾、肾上腺、乳腺、骨等组织,其作为核转录因子参与人体多种复杂生理过程的调节。ERα受体表达和调节的研究对多种疾病的预防和治疗有积极意义,例如癌症、代谢性疾病、心血管疾病、神经退行性疾病、炎症和骨质疏松症等[1]。蛋白表达在ERα受体表达调节研究中占有重要地位,而ERα抗体则是ERα受体表达的重要研究工具。 

      ERα受体包括多个功能结构域,不同的转录剪接产生不同的转录异构体[2],主要包括ERα36和ERα46。由于与疾病的密切相关性,ERα36、ERα46和野生型ERα (ERα66)一起成为ER家族研究热点,相应的抗体也成为对应的研究工具。美国CHI Scientific提供的 ERα系列(ER-α36, ER-α46 & 66, ER-α36)抗体灵敏度高,特异性强,自面试以来,引用该系列产品的文献达上百篇。尤其是Anti-hER-α36抗体,为美国CHI Scientific生产销售的产品,为广大中外科研学者研究ERα36相关疾病提供强有力支撑。


论文截图:
 

Anti-hER-α36

The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 20 amino acids of hER-α36. The specificity of the antibody was tested in hER-α36 expression vector transfected HEK293 cells that do not express endogenous hER-α. Immunofluorescence was used to demonstrate immunoreactive signals only in transfectants with the hER-α36-expressing vectors but not in transfectants harboring an empty expression vector. This rabbit polyclonal anti-hER-α36 antibody is supplied in affinity-purified form.

(引用SCI论文截图)

Anti-hER-α46 & ER-α66:

The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 18 amino acids of hER-α66. The specificity of the antibody was tested in hER-α46 and hER-α66 expression cells, MCF-7 Cells and breast carcinoma tissues. This rabbit polyclonal anti-hER-α46 & hER-α66 antibody is supplied in affinity-purified form.

(引用SCI论文截图)

Anti-hER-α66

 The antibody was raised against a synthetic peptide antigen corresponding to the unique C-terminal 18 amino acids of hER-α66. The specificity of the antibody was tested in hER-α66 expression cells, MCF-7 Cells and breast carcinoma tissues. This rabbit polyclonal anti-hER-α66 antibody is supplied in affinity-purified form.

(引用SCI论文截图)

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更多引用:

1.Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancerA Verma, N Schwartz, DJ Cohen, BD Boyan… - Steroids, 2019 - Elsevier 

2.24R, 25-dihydroxyvitamin D3 modulates tumorigenicity in breast cancer in an estrogen receptor-dependent mannerA Verma, Z Schwartz, BD Boyan - Steroids, 2019 - Elsevier 

3.Effect of 17β-estradiol on estrogen receptor negative breast cancer cells in an osteolytic mouse modelDJ Cohen, V Patel, A Verma, BD Boyan, Z Schwartz - Steroids, 2019 - Elsevier 

 

4.Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomesN Schwartz, A Verma, C Muktipaty, C Bivens… - Steroids, 2019 - Elsevier

 

5.Estrogen receptor-alpha 36 mediates the anti-apoptotic effect of estradiol in triple negative breast cancer cells via a membrane-associated mechanismRA Chaudhri, A Hadadi, KS Lobachev… - … et Biophysica Acta (BBA …, 2014 - Elsevier 

6.Membrane estrogen signaling enhances tumorigenesis and metastatic potential of breast cancer cells viaestrogen receptor-α36 (ERα36)RA Chaudhri, R Olivares-Navarrete, N Cuenca… - Journal of Biological …, 2012 - ASBMB